News

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June 26, 2014
NEW PUBLICATION

Prolonged expression of an anti-HIV-1 gp120 minibody to the female rhesus macaque lower genital tract by AAV gene transfer.

May 27-29, 2014
Dr. Marasco speaking at the MENA meeting in Doha, Qatar

May 1, 2014
NEW PUBLICATION

Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Ab against Flu

April 28, 2014
NEW PUBLICATION

Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution


Announcements

Launch of Humanized Mouse Program

The Marasco Lab Humanized Mouse Program is open to the research community
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www.humouse.org

Project Highlight:
Emerging Infectious Disease: Broadly Neutralizing Antibody Responses (BnAb) to the Influenza Viruses

 

Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies Against Influenza A Viruses

  1. Molecular signatures occur in the VH domain of anti-influenza stem Abs.
  2. Rare VH-segment signatures occur in non-classical somatic hypermutation positions.
  3. Anti-influenza stem BnAbs can be generated with as few as one VH substitutions.
  4. Distinctive CDR-H2 substitutions facilitate HA binding of anchor residues.

Left - The location of F10 binding on the HA is shown with HA1 colored in salmon and HA2 colored in grey.  Right panel – The location of contact CDR residues. In light green is the HA2 fusion peptide from Trp212-to-Val182.